脳を再構築できるのか？ | ショーン・シモニーニ | TEDxBoston Salon

神経変性疾患、外傷性脳損傷、脳卒中、加齢による衰えは、脳が新しいニューロンを作る能力が乏しいため、長く不可逆的なものと考えられてきました。TEDxBoston Salonでの講演で、Sequel Neuroscienceの共同創業者兼CEOであるショーン・シモニーニ氏は、新しいニューロンを脳に移植することで、こうした損傷の一部を元に戻せる可能性を論じています。パーキンソン病での初期の試験から現在の研究まで、細胞置換療法の流れを紹介しています。

• 脳の損傷が長く不可逆と考えられてきた理由
• パーキンソン病の初期試験から現在までの細胞置換療法
• 残された組織を守るだけでなく、失われた脳組織を回復させる考え方

NOTE FROM TED: Research discussed in this talk remains an ongoing field of study. TEDx events are independently organized by volunteers. The guidelines we give TEDx organizers are described in more detail here: http://storage.ted.com/tedx/manuals/tedx_content_guidelines.pdf When neurons die, our brains have little capacity to make new ones. This has meant that neurodegenerative conditions, traumatic brain injuries, strokes, and age-related decline have all been considered permanent and irreversible. Sean Simonini learned this the hard way, but sees hope in our ability to reverse this damage by transplanting new neurons into the brain. He traces how cell replacement therapies, from early trials in Parkinson’s to cutting edge science, are beginning to break the long-held belief that damage to the brain could never be undone. He argues that neurology is shifting from preserving what is left, to restoring what was lost, and asks what this means when new cells become a part of us. Sean Simonini is a Co-Founder & CEO of Sequel Neuroscience which is working on regenerative therapies for stroke, ALS, and other brain conditions. Previously, he was a researcher at the University of California, San Francisco and Harvard University, studying stem cell biology and neurodevelopment. He also led several nonprofits to grow the Boston biotech ecosystem, support public education, and address food insecurity. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx